详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Melanocortin-4 receptor expression in the rostral ventromedial medulla involved in modulation of nociception in transgenic mice

58| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Med Assoc Hubei Prov, Wuhan 430060, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol & Pain Med, Tongji Med Coll, Wuhan 430030, Peoples R China [3]Guangdong Prov Hosp Tradit Chinese Med, Dept Dermatol, Guangzhou 510120, Guangdong, Peoples R China

出处：

DOI：

ISSN：

关键词： melanocortin-4 receptor nociception rostral ventromedial medulla

摘要：

The rostral ventromedial medulla (RVM) is a prominent component of the descending modulatory system involved in the control of spinal nociceptive transmission. In the current study, we investigated melanocortin-4 receptor (MC4R) expression in the RVM, where the neurons involved in modulation of nociception reside. Using a line of mice expressing green fluorescent protein (GFP) under the control of the MC4R promoter, we found a large number of GFP-positive neurons in the RVM [nucleus raphe magnus (NRM) and nucleus gigantocellularis pars alpha (NGC alpha)]. Fluorescence immunohistochemistry revealed that approximately 10% of MC4R-GFP-positive neurons coexpressed tyrosine hydroxylase, indicating that they were catecholaminergic, whereas 50%-75% of those coexpressed tryptophan hydroxylase, indicating that they were serotonergic. Our findings support the hypothesis that MC4R signaling in RVM may modulate the activity of serotonergic sympathetic outflow sensitive to nociceptive signals, and that MC4R signaling in RVM may contribute to the descending modulation of nociceptive transmission.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2012]版：

大类 | 4 区医学

小类 | 4 区生化与分子生物学

最新[2025]版：

无

JCR分区：

出版当年[2011]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

无

影响因子： 0 最新[2023版] 0 最新五年平均 0.385 出版当年[2011版] 0 出版当年五年平均 0.405 出版前一年[2010版] 0.581 出版后一年[2012版]

第一作者：

第一作者单位： [1]Med Assoc Hubei Prov, Wuhan 430060, Peoples R China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Motor cortex-periaqueductal gray-rostral ventromedial medulla neuronal circuitry may involve in modulation of nociception by melanocortinergic-opioidergic signaling [2]Melanocortin-4 receptor in subthalamic nucleus is involved in the modulation of nociception [3]Melanocortin-4 receptor in subthalamic nucleus is involved in the modulation of nociception. [4]Inhibition of glial activation in rostral ventromedial medulla attenuates mechanical allodynia in a rat model of cancer-induced bone pain [5]Inhibition of itch-related responses by selectively ablated serotonergic signals at the rostral ventromedial medulla in mice [6]Inhibition of itch-related responses by selectively ablated serotonergic signals at the rostral ventromedial medulla in mice [7]Melanocortin-4 receptor regulation of pain [8]Inhibition of itch-related responses by selectively ablated serotonergic signals at the rostral ventromedial medulla in mice. [9]Inhibition of itch-related responses by selectively ablated serotonergic signals at the rostral ventromedial medulla in mice [10]Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling