单位：[1]Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院麻醉科[2]Department of Surgery, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院外科学系外科学系[3]Cancer Center, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院肿瘤科[4]Department of Gynecology, Shenzhen Second People’s Hospital, Shenzhen, China[5]Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Bone cancer pain (BCP) is still an intractable problem currently because the analgesic pharmacological intervention remains insufficient. Thus, the development of novel therapeutic target is critical for the treatment of BCP. Emerging evidence demonstrated that some chemokines and their receptors contribute to the induction and maintenance of BCP. In this article, we reviewed the current evidence for the role of different chemokines and their receptors (e.g. CXCL12/CXCR4, CXCL1/CXCR2, CCL2/CCR2, CCL5/CCR5, CX3CL1/CX3CR1 and CXCL10/CXCR3) in mediating BCP. By extensively understanding the involvement of chemokines and their receptors in BCP, novel therapeutic targets may be revealed for the treatment of BCP.
基金：
National Natural Science Foundation of P.R. ChinaNational Natural Science Foundation of China (NSFC) [81400917]; National Natural Science Foundation of Hubei Province [2014CFB449]; Clinical Key Disciplines Construction Grant from the Ministry of Health of P.R. China; Wuhan Municipal Human Resources and Social Security Bureau, Specialized Research Fund for the Doctoral Program of Higher Education [20130142120102, 2014QT021]; Shenzhen Science and Technology Innovation Committee [GJHZ20130412153906741]
第一作者单位：[1]Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
共同第一作者：
通讯作者：
通讯机构：[5]Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
推荐引用方式(GB/T 7714)：
Zhou Ya-Qun,Gao Heng-Yi,Guan Xue-Hai,et al.Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain[J].CURRENT PHARMACEUTICAL DESIGN.2015,21(34):5029-5033.doi:10.2174/1381612821666150831141931.
APA：
Zhou, Ya-Qun,Gao, Heng-Yi,Guan, Xue-Hai,Xun Yuan,Fang, Guang-Guang...&Ye, Da-Wei.(2015).Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain.CURRENT PHARMACEUTICAL DESIGN,21,(34)
MLA：
Zhou, Ya-Qun,et al."Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain".CURRENT PHARMACEUTICAL DESIGN 21..34(2015):5029-5033
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