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NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Orthoped,Tongji Med Coll,Wuhan 430030,Peoples R China

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关键词： fibroblast-like synoviocytes NF-kappa B NLRP6 rheumatoid arthritis TAB2/3

摘要：

In the present study, we investigated the role of nucleotide oligomerization domain-like receptor family pyrin domain containing 6 (NLRP6) in rheumatoid arthritis (RA) and explored the underlying mechanism. We found that both mRNA and protein levels of NLRP6 are attenuated in synovial tissues and fibroblast-like synoviocytes (FLS) of RA patients compared to patients with osteoarthritis. We also observed that pro-inflammatory cytokine production is decreased and nuclear factor-kappa B activation is inhibited in NLRP6-overexpressing RA-FLS. Furthermore, we found that NLRP6 overexpression promotes transforming growth factor-b-activated kinase 1-binding protein 2/3 lysosome-dependent degradation, and we provide evidence showing that NLRP6 plays the role of providing the docking site to facilitate the interaction between transforming growth factor-b-activated kinase 1-binding protein 2/3 and tripartite motif 38 in RA-FLS.

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出版当年[2016]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 3 区生物物理 3 区细胞生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2015]版：

Q2 CELL BIOLOGY Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 BIOPHYSICS

最新[2023]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3 最新[2023版] 3.8 最新五年平均 3.519 出版当年[2015版] 3.478 出版当年五年平均 3.169 出版前一年[2014版] 3.623 出版后一年[2016版]

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第一作者单位： [1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Orthoped,Tongji Med Coll,Wuhan 430030,Peoples R China

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