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Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis

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单位： [1]Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]Department of Rheumatology and Immunology, Zhongnan Hospital, Wuhan University, Wuhan, China. [3]Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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关键词： oncostatin M (OSM) rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) cytokines cartilage and bone destruction CD4+ T cell pannus formation

摘要：

Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is a pleiotropic cytokine that primarily activates the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and other physiological processes such as cell proliferation, inflammatory response, immune response, and hematopoiesis through its receptor complex. In this review, we first describe the characteristics of OSM and its receptor, and the biological functions of OSM signaling. Subsequently, we discuss the possible roles of OSM in the development of RA from clinical and basic research perspectives. Finally, we summarize the progress of clinical studies targeting OSM for the treatment of RA. This review provides researchers with a systematic understanding of the role of OSM signaling in RA, which can guide the development of drugs targeting OSM for the treatment of RA.Copyright © 2023 Han, Yan, Li, Lin, Huang, Shen, Ba, Huang, Qin, Geng, Wang, Zheng, Liu, Wang, Chen and Tu.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

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出版当年[2021]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 8.787 出版当年[2021版] 8.877 出版当年五年平均 7.561 出版前一年[2020版] 7.3 出版后一年[2022版]

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第一作者单位： [1]Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.

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