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Minocycline as a promising therapeutic strategy for chronic pain

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收录情况： ◇ SCIE

作者：

单位： [1]Anesthesiology Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Department of Anesthesiology and Pain Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Department of Orthopaedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [4]Cancer Center,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China

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关键词： Minocycline Chronic pain Microglia Astrocyte Cytokines

摘要：

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies. Minocycline is a member of the tetracycline class of antibiotics, which has been used in clinic for decades. It is frequently reported that minocycline may has many non-antibiotic properties, among which is its anti-nociceptive effect. The results from our lab and others suggest that minocycline exerts strong analgesic effect in animal models of chronic pain including visceral pain, chemotherapy-induced periphery neuropathy, periphery injury induced neuropathic pain, diabetic neuropathic pain, spinal cord injury, inflammatory pain and bone cancer pain. In this review, we summarize the mechanisms underlying the analgesic effect of minocycline in preclinical studies. Due to a good safety record when used chronically, minocycline may become a promising therapeutic strategy for chronic pain in clinic.

基金：

基金编号： 81400917 81401762 81371250 81571053

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出版当年[2017]版：

大类 | 2 区医学

小类 | 2 区药学

最新[2025]版：

大类 | 2 区

医学

小类 | 1 区药学

JCR分区：

出版当年[2016]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 9.1 最新[2023版] 9 最新五年平均 4.48 出版当年[2016版] 4.497 出版当年五年平均 4.816 出版前一年[2015版] 4.897 出版后一年[2017版]

第一作者：

第一作者单位： [1]Anesthesiology Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Department of Anesthesiology and Pain Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

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