个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

The bidirectional roles of the cGAS-STING pathway in pain processing: Cellular and molecular mechanisms

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Hu Yingjie[1,2,3] * ; Chen Yuye[1,2,3] ; Liu Tongtong[1,2,3] ; Zhu Chang[1,2,3] ; Wan Li[1,2,3] ; Yao Wenlong[1,2,3,*1] ;
单位： [1]Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Huazhong University of Science and Technology, Wuhan 430030, China [2]Wuhan Clinical Research Center for Geriatric Anesthesia, Huazhong University of Science and Technology, Wuhan 430030, China [3]Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
出处：
DOI： 10.1016/j.biopha.2023.114869
ISSN：

关键词： Astrocyte cGAS-STING Chronic pain Microglia Neuroinflammation Nociceptive neuron

摘要：
Pain is a common clinical condition. However, the mechanisms underlying pain are not yet fully understood. It is known that the neuroimmune system plays a critical role in the pathogenesis of pain. Recent studies indicated that the cyclic-GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway can activate the innate immune system by sensing both extrinsic and intrinsic double-stranded DNA in the cytoplasm, which is involved in pain processing. In this review, we summarise (1) the roles of the cGAS-STING pathway in different pain models, (2) the effect of the cGAS-STING pathway in different cells during pain regulation, and (3) the downstream molecular mechanisms of the cGAS-STING pathway in pain regulation. This review provides evidence that the cGAS-STING pathway has pro- and anti-nociceptive effects in pain models. It has different functions in neuron, microglia, macrophage, and T cells. Its downstream molecules include IFN-I, NF-κB, NLRP3, and eIF2α. The bidirectional roles of the cGAS-STING pathway in pain processing are mediated by regulating nociceptive neuronal sensitivity and neuroinflammatory responses. However, their effects in special brain regions, activation of astrocytes, and the different phases of pain require further exploration.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

基金：
National Natural Science Foundation of China (Grant Nos. 82171228 and 82201387).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 1 区 药学 2 区 医学：研究与实验
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 2 区 药学
JCR分区：
出版当年[2021]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Huazhong University of Science and Technology, Wuhan 430030, China [2]Wuhan Clinical Research Center for Geriatric Anesthesia, Huazhong University of Science and Technology, Wuhan 430030, China [3]Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
通讯作者：
通讯机构： [1]Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Huazhong University of Science and Technology, Wuhan 430030, China [2]Wuhan Clinical Research Center for Geriatric Anesthesia, Huazhong University of Science and Technology, Wuhan 430030, China [3]Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [*1]Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,Wuhan Clinical Research Center for Geriatric Anesthesia,Department of Anesthesiology,Tongji Hospital,Tongji Medical College Huazhong University of Science and Technology,Wuhan 430030,China
推荐引用方式(GB/T 7714)：
Hu Yingjie,Chen Yuye,Liu Tongtong,et al.The bidirectional roles of the cGAS-STING pathway in pain processing: Cellular and molecular mechanisms[J].BIOMEDICINE & PHARMACOTHERAPY.2023,163:doi:10.1016/j.biopha.2023.114869.
APA：
Hu Yingjie,Chen Yuye,Liu Tongtong,Zhu Chang,Wan Li&Yao Wenlong.(2023).The bidirectional roles of the cGAS-STING pathway in pain processing: Cellular and molecular mechanisms.BIOMEDICINE & PHARMACOTHERAPY,163,
MLA：
Hu Yingjie,et al."The bidirectional roles of the cGAS-STING pathway in pain processing: Cellular and molecular mechanisms".BIOMEDICINE & PHARMACOTHERAPY 163.(2023)

相关文献

[1]Minocycline as a promising therapeutic strategy for chronic pain [2]Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain [3]Targeting α7 nicotinic acetylcholine receptors for chronic pain [4]Activation of mitochondrial DNA-mediated cGAS-STING pathway contributes to chronic postsurgical pain by inducing type I interferons and A1 reactive astrocytes in the spinal cord [5]Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway [6]Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases [7]Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury [8]Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. [9]Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway. [10]The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection

资源点击量：589 今日访问量：0 总访问量：441 更新日期：2025-06-01 建议使用谷歌、火狐浏览器 常见问题

版权所有：重庆聚合科技有限公司 渝ICP备12007440号-3 地址：重庆市两江新区泰山大道西段8号坤恩国际商务中心16层（401121）