Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.
基金：
National Natural Science Foundation of China [31201052, 81802815]
第一作者单位：[1]Jilin Univ, Coll Basic Med Sci, Key Lab Pathobiol, Minist Educ, Changchun, Jilin, Peoples R China
通讯作者：
通讯机构：[4]Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China[5]Jilin Univ, Inst Immunol, Changchun, Jilin, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Wenqi,Xia Peng,Wang Heping,et al.The endothelial tip-stalk cell selection and shuffling during angiogenesis[J].JOURNAL OF CELL COMMUNICATION AND SIGNALING.2019,13(3):291-301.doi:10.1007/s12079-019-00511-z.
APA：
Chen, Wenqi,Xia, Peng,Wang, Heping,Tu, Jihao,Liang, Xinyue...&Li, Lisha.(2019).The endothelial tip-stalk cell selection and shuffling during angiogenesis.JOURNAL OF CELL COMMUNICATION AND SIGNALING,13,(3)
MLA：
Chen, Wenqi,et al."The endothelial tip-stalk cell selection and shuffling during angiogenesis".JOURNAL OF CELL COMMUNICATION AND SIGNALING 13..3(2019):291-301
