The lifetime prevalence of addiction to cannabis (marijuana or cannabinoids) is among the highest of that of all illicit drugs in developed countries, and no effective treatment for cannabis addiction is currently available. Previous studies in our research group suggested that astrocyte-mediated long-term depression (LTD) in ventral tegmental area (VTA) dopamine neurons plays a pivotal role in the development of cannabis addiction. The present study was designed to investigate the effects and potential mechanisms of riluzole, a drug used for the treatment of motor neuron diseases, on cannabinoid-facilitated LTD induction. We demonstrated that riluzole significantly inhibited HU210-induced glutamate release through increased expression of glial glutamate transporter-1 (GLT-1) in cultured astrocytes, and an infusion of riluzole into the bilateral VTA in rats prevented the potent cannabinoid HU210-facilitated LTD induction in 2-month-old animals, which was blocked by bath application of dihydrokainate (DHK), a selective GLT-1 inhibitor. Our results show the effects and potential mechanism of action of riluzole in cannabinoid-facilitated LTD induction, which may provide insights into new therapeutic approaches for cannabis addiction.
基金：
National Key R&D Program of China [2017YFC1310000]; Science and Technology Support Plan of Hubei Province [2015BKA220]
第一作者单位：[1]Shaanxi Normal Univ, Ctr Teacher Profess Abil Dev, MOE Key Lab Modern Teaching Technol, 113,199,South Changan Rd, Xian 710062, Shaanxi, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Zhiqiang,Xu Yi,Zhang Xiaofan,et al.Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes[J].NEUROSCIENCE LETTERS.2019,704:201-207.doi:10.1016/j.neulet.2019.04.021.
APA：
Liu, Zhiqiang,Xu, Yi,Zhang, Xiaofan,Miao, Jinfeng,Han, Jing&Zhu, Zhou.(2019).Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes.NEUROSCIENCE LETTERS,704,
MLA：
Liu, Zhiqiang,et al."Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes".NEUROSCIENCE LETTERS 704.(2019):201-207
