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Heterosynaptic long-term depression mediated by ATP released from astrocytes

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单位： [1]Zhejiang Univ, Sch Med, Key Lab Neurobiol Zhejiang Prov, Minist Hlth China,Dept Neurobiol,Key Lab Med Neur, Hangzhou 310003, Zhejiang, Peoples R China [2]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China [3]Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Neurosci, Shanghai, Peoples R China [4]Huazhong Univ Sci & Technol,Tongji Med Sch,Tongji Hosp,Dept Neurol,Wuhan 430074,Peoples R China

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关键词： heterosynaptic long-term depression astrocytes channelrhodopsin-2 P2Y receptors ATP

摘要：

Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induced ATP release from astrocytes that suppresses transmitter release from untetanized synaptic terminals via activation of P2Y receptors. Selective stimulation of astrocytes expressing channelrhodopsin-2, a light-gated cation channel permeable to Ca2+, resulted in LTD of synapses on neighboring neurons. This synaptic modification required Ca2+ elevation in astrocytes and activation of P2Y receptors, but not N-methyl-D-aspartate receptors. Furthermore, blocking P2Y receptors or buffering astrocyte intracellular Ca2+ at a low level prevented hLTD without affecting LTP induced by SC stimulation. Thus, astrocyte activation is both necessary and sufficient for mediating hLTD accompanying LTP induction, strongly supporting the notion that astrocytes actively participate in activity-dependent synaptic plasticity of neural circuits. (c) 2012 Wiley Periodicals, Inc.

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出版当年[2012]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区神经科学

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出版当年[2011]版：

Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.4 最新[2023版] 6.6 最新五年平均 4.82 出版当年[2011版] 5.157 出版当年五年平均 5.186 出版前一年[2010版] 5.066 出版后一年[2012版]

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第一作者单位： [1]Zhejiang Univ, Sch Med, Key Lab Neurobiol Zhejiang Prov, Minist Hlth China,Dept Neurobiol,Key Lab Med Neur, Hangzhou 310003, Zhejiang, Peoples R China [2]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China [3]Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Neurosci, Shanghai, Peoples R China

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