Objective: This study aimed to explore the effects of clinical nursing pathway (CNP) in gynecological bedridden patients and its impact on the incidence of bedsores. Method: 150 patients (Braden score <18 points) were randomly divided into the study group (n=75) and control group (n=75). Conventional care was performed in the control group, and CNP, which required regular scoring as well as effective dietary and psychological guidance, was performed in the study group. The incidence of bedsores, the cure rate, the surface pressure of the compression site, changes in skin temperature, and patients' satisfaction with the nursing care provided were observed. Results: There was no significant difference between the study group and the control group in terms of gender, age, alcohol consumption, smoking, body mass index, etiology, and alanine aminotransferase and aspartate aminotransferase levels (all P>0.05). The incidence of bedsores was significantly lower (chi(2)=4.701, P=0.048) but the cure rate of bedsores was significantly higher (chi(2)=5.304, P=0.027) in the study group than in the control group. The skin temperatures of the scapula and the appendix (t=4.778, P<0.001; t=3.530, P<0.001) and surface pressure of the scapula and the appendix (t=2.641, P=0.009; t=2.299, P=0.022) were significantly lower in the study group than in the control group. The satisfaction rate of the study group with the nursing care provided was significantly higher than that of the control group (chi(2)=8.027, P=0.008). Conclusion: The application of the CNP nursing intervention model in gynecological bedridden patients reduced the incidence of bedsores, the epidermal temperature and surface pressure of the compressed parts, and improved patients' bedsores, and satisfaction with nursing care.