Background With the development and progression of genetic technology, preimplantation genetic testing (PGT) has made it possible to block the inheritance of autosomal dominant polycystic kidney disease (ADPKD) as early as possible. However, we need to know the patients' fertility intentions and their acceptance of PGT. Methods A questionnaire survey was conducted to collect data on the basic demographic data, quality of life, social support, fertility willingness, and level of understanding of genetic testing for blocking the inheritance of ADPKD among patients aged 18-45 years in seven hospitals from January 2018 to December 2018. After verification, statistics were calculated. Results A total of 260 patients with ADPKD were interviewed, including 137males (52.7%) and 123 females (47.3%). The overall fertility willingness rate was low (n = 117, 45.0%). The proportion of married patients aged 25-34 years that were at the optimal reproductive age but did not yet have children was relatively high (n = 77, 67.0%). The fertility intentions of ADPKD patients were significantly influenced by age (OR: 0.101, 95% CI 0.045-0.225, P < 0.001) and education level (OR: 2.134, 95% CI 1.162-3.917, P = 0.014). Among patients who are willing to have children, 207 (79.6%) of them would choose PGT technology. Among those who were not sure whether they would choose PGT technology, the first major concern was technical safety (49.2%). Conclusions The reproductive desire of childbearing ADPKD patients in China was low. Strengthening the health education of ADPKD genetic knowledge and reducing the cost of related technologies may improve the fertility intentions and reduce the barriers to acceptance of PGT.
基金：
National Key Research and Development Program of China [2016YFC0901502]; National Natural Science Foundation of China [81873595, 81670612]; Shanghai Top Priority Key Clinical Disciplines Construction Project [2017ZZ02009]; Shanghai Shenkang Hospital Development Center Clinical Science and Technology Innovation Project [SHDC12017X26]; Shanghai Science and Technology Talents Program [19YF1450300]
第一作者单位：[1]Second Mil Med Univ, Changzheng Hosp, Dept Nephrol, 415 Fengyang Rd, Shanghai 200003, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Mingji,Xue Cheng,Lu Yunhui,et al.The fertility willingness and acceptability of preimplantation genetic testing in Chinese patients with autosomal dominant polycystic kidney disease[J].BMC NEPHROLOGY.2020,21(1):doi:10.1186/s12882-020-01785-x.
APA：
Sun, Mingji,Xue, Cheng,Lu, Yunhui,Ma, Yiyi,Pan, Ting...&Mei, Changlin.(2020).The fertility willingness and acceptability of preimplantation genetic testing in Chinese patients with autosomal dominant polycystic kidney disease.BMC NEPHROLOGY,21,(1)
MLA：
Sun, Mingji,et al."The fertility willingness and acceptability of preimplantation genetic testing in Chinese patients with autosomal dominant polycystic kidney disease".BMC NEPHROLOGY 21..1(2020)
