Iron depletion is an efficient strategy for the development of anticancer agents. In an effort to develop efficient chelators, two new 3-hydroxy-4-pyridinone based polyazamacrocycles 1e and 2e were designed and synthesized. A preliminary study of the ligands was carried out to investigate their iron chelating capability and antitumor activity. Chelating kinetics revealed that the ligands exhibited excellent iron depletion capacity in neutral and acidic NH4OAc buffer solutions. Moreover, MTT assay showed that the new ligands displayed potent inhibitory activity in the proliferation of HepG2 cells. The attachment of hydroxypyridione units on the polyazamacrocycles promoted iron chelating capability and improved the anti-tumor activity by offering additional chelating sites and lipophilicity. These results indicate that two novel compounds may possess the therapeutic potential in the treatment of cancer through depleting cellular iron.
基金：
Natural Science Foundation of China [81603046, 81673368, 81703446, 81973257]; Independent Innovation Foundation of Higher Education of China [2016JCTD109, 2016YXMS140, 2016YXMS147]; National Postdoctoral Program for Innovative Talents [BX201600057]; China Postdoctoral Science Foundation, China [2017M612474]; Fundamental Research Funds for the Central Universities, China [HUST: 2018JYCXJJ008]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, 13 Hangkong Rd, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Xiaoguang,Dong Xiuxiu,He Chuanchuan,et al.New polyazamacrocyclic 3-hydroxy-4-pyridinone based ligands for iron depletion antitumor activity[J].BIOORGANIC CHEMISTRY.2020,96:doi:10.1016/j.bioorg.2020.103574.
APA：
Liu, Xiaoguang,Dong, Xiuxiu,He, Chuanchuan,Zhang, Xiaojuan,Xiang, Guangya&Ma, Xiang.(2020).New polyazamacrocyclic 3-hydroxy-4-pyridinone based ligands for iron depletion antitumor activity.BIOORGANIC CHEMISTRY,96,
MLA：
Liu, Xiaoguang,et al."New polyazamacrocyclic 3-hydroxy-4-pyridinone based ligands for iron depletion antitumor activity".BIOORGANIC CHEMISTRY 96.(2020)
