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The role of deubiquitinases in cardiac disease

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收录情况： ◇ SCIE

作者：

单位： [1]Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

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关键词： cardiac disease cardiac fibrosis cardiac hypertrophy deubiquitinases myocardial ischaemia-reperfusion injury myocarditis

摘要：

Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future.

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出版当年[2023]版中科院分区表Review为是的期刊

：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 3 区医学：研究与实验

最新[2025]版

：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区医学：研究与实验

JCR分区：

出版当年[2022]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.5 最新[2023版] 5.6 最新五年平均 6.2 出版当年[2022版] 6.3 出版当年五年平均 7.615 出版前一年[2021版] 4.5 出版后一年[2023版]

第一作者：

第一作者单位： [1]Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

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