单位：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.口腔科华中科技大学同济医学院附属同济医院[2]Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regen-Eration, Wuhan 430022, China.
Glioma-associated oncogene homolog 1 (Gli1) is a transcriptional activator of hedgehog (Hh) signaling that regulates target gene expression and several cellular biological processes. Cell lineage tracing techniques have highlighted Gli1 as an ideal marker for mesenchymal stem cells (MSCs) in vivo. Gli1+ MSCs are critical for the osteogenesis of the craniofacial bone; however, the regulatory mechanism by which Gli1+ MSCs mediate the bone development and tissue regeneration of craniofacial bone has not been systematically outlined. This review comprehensively elucidates the specific roles of Gli1+ MSCs in craniofacial bone osteogenesis. In addition to governing craniofacial bone development, Gli1+ MSCs are associated with the tissue repair of craniofacial bone under pathological conditions. Gli1+ MSCs promote intramembranous and endochondral ossification of the craniofacial bones, and assist the osteogenesis of the craniofacial bone by improving angiopoiesis. This review summarizes the novel role of Gli1+ MSCs in bone development and tissue repair in craniofacial bones, which offers new insights into bone regeneration therapy.
基金：
This work was supported by grants from the General Program of National Natural Science
Foundation of China (No. 82170933), and the Natural Science Foundation of Hubei Province for
Distinguished Young Scholars (No. 2023AFA106).
第一作者单位：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[2]Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regen-Eration, Wuhan 430022, China.
通讯作者：
通讯机构：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[2]Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regen-Eration, Wuhan 430022, China.
推荐引用方式(GB/T 7714)：
Wu Laidi,Liu Zhixin,Xiao Li,et al.The Role of Gli1+ Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone[J].BIOMOLECULES.2023,13(9):doi:10.3390/biom13091351.
APA：
Wu Laidi,Liu Zhixin,Xiao Li,Ai Mi,Cao Yingguang...&Song Ke.(2023).The Role of Gli1+ Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone.BIOMOLECULES,13,(9)
MLA：
Wu Laidi,et al."The Role of Gli1+ Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone".BIOMOLECULES 13..9(2023)
