Implants that can inhibit osteoclastogenesis and enhance osteogenesis are desirable for osteoporosis patients. In this study, titania nanotube (Ti-NT) materials, having nanotube diameters of 30, 80, and 120 nm, were produced separately by anodization at 10, 40, and 60 V, respectively. The introduction of Ti-NTs to titanium substrates significantly reduced the formation and activity of osteoclasts on samples. With the enlargement of the nanotube diameter, the osteoclasts number, tartrate-resistant acid phosphatase staining and activity, and related gene expressions of osteoclasts were further reduced. Osteogenic ability was enhanced by increasing the nanotube diameter. Thus, larger-diameter nanotube implants, such as NT60, were better able to inhibit bone absorption and enhance bone formation to prevent implant loss and failure, especially for osteoporosis patients.
基金：
National Natural Science Foundation of China [81271934]; Specialized Research Fund for the Health Industry of the Ministry of Health [201002018]; Fundamental Research Funds for the Central Universities [2013YGYL017]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Orthoped,Wuhan 430030,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yong,Li Feng,Zhang Chengcheng,et al.The Dimension of Titania Nanotubes Influences Implant Success for Osteoclastogenesis and Osteogenesis Patients[J].JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY.2015,15(6):4136-4142.doi:10.1166/jnn.2015.9602.
APA：
Li, Yong,Li, Feng,Zhang, Chengcheng,Gao, Biao,Tan, Peng...&Xiong, Wei.(2015).The Dimension of Titania Nanotubes Influences Implant Success for Osteoclastogenesis and Osteogenesis Patients.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,15,(6)
MLA：
Li, Yong,et al."The Dimension of Titania Nanotubes Influences Implant Success for Osteoclastogenesis and Osteogenesis Patients".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15..6(2015):4136-4142
