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HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy

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收录情况： ◇ SCIE

作者：
Ling Jianmin[1] * ; Yu Shanshan[1] ; Xiong Feng[1] ; Li Shusheng[1,*1] ;
单位： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China [2]Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China
出处：
DOI： 10.1016/j.intimp.2023.110448
ISSN：

关键词： Sepsis-associated encephalopathy Cognitive impairment HSPB8 Mitochondria

摘要：
Sepsis-associated encephalopathy (SAE) is associated with a higher risk of cognitive deficits; however, its potential mechanisms are still unknow. Recently, researches show that HSPB8, a family of small heat shock proteins, affects cognitive function and ameliorates sepsis-induced dysfunction. However, the role of HSPB8 in SAE-associated cognitive impairment has not been elucidated. In this study, we found that HSPB8 expression was up-regulated in the brain of mice with lipopolysaccharide-induced sepsis. HSPB8 overexpression alleviated cognitive decline in SAE mice. In addition, exogenous HSPB8 exerts neuroprotective effects and salvages synaptic function via regulating NRF1/TFAM-induced mitochondrial biogenesis and DRP1-mediate mitochondrial fission in a lipopolysaccharide-induced mouse model. Furthermore, HSPB8 overexpression inhibits IBA1 and NLRP3 activation in the SAE model. Overexpression of HSPB8 may be an efficient treatment for relieving SAE-related cognitive decline.Copyright © 2023. Published by Elsevier B.V.

基金：
This work was supported by Scientific Research Foundation of Tongji Hospital (2201103255).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
JCR分区：
出版当年[2021]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China
通讯作者：
通讯机构： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China [*1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Dadao, Wuhan 430000, China
推荐引用方式(GB/T 7714)：
Ling Jianmin,Yu Shanshan,Xiong Feng,et al.HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2023,122:doi:10.1016/j.intimp.2023.110448.
APA：
Ling Jianmin,Yu Shanshan,Xiong Feng&Li Shusheng.(2023).HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy.INTERNATIONAL IMMUNOPHARMACOLOGY,122,
MLA：
Ling Jianmin,et al."HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy".INTERNATIONAL IMMUNOPHARMACOLOGY 122.(2023)

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