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Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice

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收录情况： ◇ SCIE

作者：
Li Yujuan[1] * ; Xie Zheng[1] ; Luo Xiaoxiao[2] ; Wang Xuan[1] ; Wang Yue[1] ; Guo Mingke[1] ; Zhou Zhiqiang[1] ; Sun Rao[1] ; Hua Dongyu[1] ; Luo Ailin[1] ; Li Shiyong[1] ;
单位： [1]Department of Anesthesiology,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,and Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,027-430030,China. [2]Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
出处：
DOI： 10.1002/mnfr.202200735
ISSN：

关键词： chronic sleep deprivation cognitive impairment Farnesol oxidative stress Sirt1/Nrf2 signaling pathway

摘要：
Sleep deprivation (SD) negatively affects all aspects of health, with one serious consequence being impaired cognition. Farnesol (FOL) is a sesquiterpene synthesized by plants and mammals that has antioxidant, anti-inflammatory, and neuroprotective properties. This study investigates the mechanism underlying the neuroprotective effect of FOL on SD-induced cognitive impairment.Administration of FOL dramatically ameliorates chronic sleep deprivation (CSD)-induced cognitive impairment. In addition, FOL notably attenuates oxidative stress damage, pro-inflammatory cytokines activation, and microglial activation in the hippocampi of the CSD-exposed mice. Further examination indicates that administration of FOL after the CSD significantly increases the protein expressions of silent information regulator factor 2-related enzyme 1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (Gpx4) in the hippocampi. Sirt1 agonist resveratrol (RES) has a similar neuroprotective effect, indicating that FOL could exert neuroprotective effects through the activation of the Sirt1/Nrf2 signaling pathway.The results reveal that FOL could protect against CSD-induced cognitive impairment by activating the Sirt1/Nrf2 signaling pathway.© 2023 Wiley-VCH GmbH.

基金：
This work was supported by the National Key R&D Program of China (Program No. 2020YFC2009002), National Natural Science Foundation of China (Grant no: 81974160), and Natural Science Foundation of Hubei Province (NO.2022CFB189).
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外文
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出版当年[2022]版：
大类 | 2 区 农林科学
小类 | 2 区 食品科技
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 食品科技
JCR分区：
出版当年[2021]版：
Q1 FOOD SCIENCE & TECHNOLOGY
最新[2023]版：
Q1 FOOD SCIENCE & TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Anesthesiology,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,and Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,027-430030,China.
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yujuan,Xie Zheng,Luo Xiaoxiao,et al.Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice[J].MOLECULAR NUTRITION & FOOD RESEARCH.2023,67(11):doi:10.1002/mnfr.202200735.
APA：
Li Yujuan,Xie Zheng,Luo Xiaoxiao,Wang Xuan,Wang Yue...&Li Shiyong.(2023).Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice.MOLECULAR NUTRITION & FOOD RESEARCH,67,(11)
MLA：
Li Yujuan,et al."Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice".MOLECULAR NUTRITION & FOOD RESEARCH 67..11(2023)

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