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In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Lei, Yongfang[2] * ; Chen, Jinglou[1] ; Zhang, Wenting[2] ; Fu, Wei[2] ; Wu, Guanghua[2] ; Wei, Han[1] ; Wang, Qing[3] ; Ruan, Jinlan[1,*1] ;
单位： [1]Huazhong Univ Sci & Technol, Coll Pharm, Tongji Med Coll, Key Lab Nat Med Chem & Resources Evaluat Hubei Pr, Wuhan 430030, Hubei Province, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pharm, Wuhan 430030, Hubei Province, Peoples R China [3]Chinese Acad Sci, Lab Wuhan Bot Garden, Wuhan, Peoples R China
出处：
DOI： 10.1016/j.foodchem.2012.07.043
ISSN：

关键词： Neuroprotective nature Flavonols Extracellular signal-regulated kinases (ERK) Cyclic AMP response element binding protein (CREB) Oxidative stress

摘要：
The potential of three natural flavonols (galangin, kaempferol and myricetin) to protect against El-galactose-induced cognitive impairment in mice was investigated. After 8 weeks treatment, the mice were assessed by behavioural tests. The levels of oxidative stress, the amount of Na+,K+-ATPase and extracellular signal-regulated kinases (ERK)-cyclic AMP response element binding protein (CREB) signaling pathway in hippocampus were also analysed. It was found that all the three dietary flavonols could ameliorate the oxidative stress, enhance the activity of Na+,K+-ATPase and regulate the expression of ERK-CREB pathway in mice. However, only kaempferol and myricetin could significantly improve the learning and memory capability when compared with D-galactose model. Our results suggest that the presence of hydroxyl groups in the B ring of flavonols may have contribution to the neuroprotective activity. (C) 2012 Elsevier Ltd. All rights reserved.

基金：
state natural science fund [30973864]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2011]版：
大类 | 2 区 工程技术
小类 | 1 区 应用化学 1 区 食品科技 2 区 营养学
最新[2025]版：
大类 | 1 区 农林科学
小类 | 1 区 应用化学 1 区 食品科技 1 区 营养学
JCR分区：
出版当年[2010]版：
Q1 NUTRITION & DIETETICS Q1 CHEMISTRY, APPLIED Q1 FOOD SCIENCE & TECHNOLOGY
最新[2023]版：
Q1 CHEMISTRY, APPLIED Q1 FOOD SCIENCE & TECHNOLOGY Q1 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

第一作者：
第一作者单位： [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pharm, Wuhan 430030, Hubei Province, Peoples R China
通讯作者：
通讯机构： [1]Huazhong Univ Sci & Technol, Coll Pharm, Tongji Med Coll, Key Lab Nat Med Chem & Resources Evaluat Hubei Pr, Wuhan 430030, Hubei Province, Peoples R China [*1]Huazhong Univ Sci & Technol, Coll Pharm, Tongji Med Coll, Key Lab Nat Med Chem & Resources Evaluat Hubei Pr, 13 Hangkong Rd, Wuhan 430030, Hubei Province, Peoples R China
推荐引用方式(GB/T 7714)：
Lei Yongfang,Chen Jinglou,Zhang Wenting,et al.In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment[J].FOOD CHEMISTRY.2012,135(4):2702-2707.doi:10.1016/j.foodchem.2012.07.043.
APA：
Lei, Yongfang,Chen, Jinglou,Zhang, Wenting,Fu, Wei,Wu, Guanghua...&Ruan, Jinlan.(2012).In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment.FOOD CHEMISTRY,135,(4)
MLA：
Lei, Yongfang,et al."In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment".FOOD CHEMISTRY 135..4(2012):2702-2707

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