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Protective effects of grape seed-derived procyanidin extract against carrageenan-induced abacterial prostatitis in rats

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pharm, Wuhan 430074, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Puai Hosp, Dept Pharm, Wuhan 430074, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Coll Pharm, Key Lab Nat Med Chem & Resources Evaluat Hubei Pr, Wuhan 430074, Peoples R China

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关键词： Grape seed-derived procyanidin extract (GSP) Prostatitis Oxidative stress Extracellular signal-regulated kinases (ERK) Inflammatory responses

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The potential of grape seed-derived procyanidin extract (GSP) to protect against carrageenan-induced abacterial prostatitis in rat was investigated. After the experimental period, the effects of GSP on the levels of prostatic interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL)-6, IL-10 and basic fibroblast growth factor (bFGF) were measured by enzyme linked immunosorbent assay. Prostatic oxidative stress was evaluated by detecting the activities of antioxidant enzymes. The prostatic levels of extracellular signal-regulated kinases (ERK) and its phosphorylation state were determined using Western blot analysis. It was found that GSP could ameliorate the carrageenan-induced ERIC over-phosphorylation state as well as the disordered levels of proinflammatory cytokines, lipid peroxidation and antioxidant enzymes. These results suggest that the GSP exerts prostate protective effects via suppressing elevated levels of ERIC phosphorylation state, proinflammatory cytokines and lipid peroxidation, and normalizing antioxidant enzyme activities. (C) 2014 Elsevier Ltd. All rights reserved.

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出版当年[2013]版：

大类 | 2 区工程技术

小类 | 3 区食品科技

最新[2025]版：

大类 | 2 区农林科学

小类 | 3 区食品科技 4 区营养学

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出版当年[2012]版：

Q1 FOOD SCIENCE & TECHNOLOGY

最新[2023]版：

Q2 FOOD SCIENCE & TECHNOLOGY Q2 NUTRITION & DIETETICS

影响因子： 3.8 最新[2023版] 4.6 最新五年平均 2.632 出版当年[2012版] 2.742 出版当年五年平均 2.446 出版前一年[2011版] 4.48 出版后一年[2013版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pharm, Wuhan 430074, Peoples R China

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