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Electrochemical signal amplification strategy based on trace metal ion modified WS2 for ultra-sensitive detection of miRNA-21

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收录情况： ◇ SCIE

作者：
Fu Sinan[1] * ; Xie Chang[2] * ; Yang Zhiruo[1] * ; Jiang Mingdi[1] ; Cheng Jing[1] ; Zhu Chengliang[3] ; Wu Kailang[4] ; Ye Huarong[5] ; Xia Wei[6] ; Jaffrezic-Renault Nicole[7] ; Guo Zhenzhong[1] ;
单位： [1]Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, 430065, PR China [2]State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China [3]Department of Clinical Laboratory, Renmin Hospital, Wuhan University, Wuhan, 430060, PR China [4]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430062, PR China [5]China Resources & Wisco General Hospital, Wuhan, 430080, PR China [6]Department of Anesthesiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, 430030, PR China [7]University of Lyon, Institute of Analytical Sciences, UMR-CNRS 5280, 5, La Doua Street, Villeurbanne, 69100, France
出处：
DOI： 10.1016/j.talanta.2023.124552
ISSN：

关键词： Metal ions screening miRNA-21 One-pot Fe3+-WS2/NrGOF Biosensor

摘要：
Previous researches have suggested the potential correlation between the development of breast cancer and the concentration of miRNA-21 in serum. Theoretically the doping of multivalent metal ions in WS2 could bring higher electron transfer capacity, but this hasn't been proven. To fill this research gap, through one-pot method we prepared seven nanocomposite structures modified with different metal ions (Co2+, Ni2+, Mn2+, Zn2+, Fe3+, Cr3+, La3+). Characterization revealed that ammonia produced by hydrothermal urea exfoliated the multilayer graphene oxide (MGO) and provided a nitrogen source for doping reduction to form a 3D flower-like structure (NrGOF) with high specific surface area. Meanwhile, the modification of WS2 by Fe3+ not only enhanced its electrochemical conductivity but also gave the material an additional peroxidase activity centre. In the composite Fe3+-WS2/NrGOF-AgNPs, NrGOF is used as a conductive loading interface for WS2, while Fe3+ served as the catalytic and electron transfer centre for secondary amplification of the electrochemical signal. The experimental results showed that the sensing platform has a low limit of detection (LOD) of 1.18 aM for miRNA-21 in the concentration range of 10-17-10-12 M and has been successfully applied to the detection of real serum samples.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was supported by National Natural Science Foundation of China, China (grant number 81973097); CNRS France, France is acknowledged for support through IRN MAREES # 0876; Outstanding Young and Middle-Aged Technology Innovation Team Project of Hubei Provincial Department of Education, China (grant number T2020003); Funded by Open Research Fund Program of the State Key Laboratory of Virology of China, China (grant number 2022KF002); Open Project Funding of the State Key Laboratory of Biocatalysis and Enzyme Engineering, China (grant number SKLBEE20220015); Provincial College Students Innovation and Entrepreneurship Training Program, China (grant number S202110488089X).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 分析化学
最新[2025]版：
大类 | 2 区 化学
小类 | 2 区 分析化学
JCR分区：
出版当年[2021]版：
Q1 CHEMISTRY, ANALYTICAL
最新[2023]版：
Q1 CHEMISTRY, ANALYTICAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, 430065, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Fu Sinan,Xie Chang,Yang Zhiruo,et al.Electrochemical signal amplification strategy based on trace metal ion modified WS2 for ultra-sensitive detection of miRNA-21[J].TALANTA.2023,260:doi:10.1016/j.talanta.2023.124552.
APA：
Fu Sinan,Xie Chang,Yang Zhiruo,Jiang Mingdi,Cheng Jing...&Guo Zhenzhong.(2023).Electrochemical signal amplification strategy based on trace metal ion modified WS2 for ultra-sensitive detection of miRNA-21.TALANTA,260,
MLA：
Fu Sinan,et al."Electrochemical signal amplification strategy based on trace metal ion modified WS2 for ultra-sensitive detection of miRNA-21".TALANTA 260.(2023)

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