个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals for cancer therapy

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xiao Chen[1] * ; Li Jiayuan[1] * ; Wang Xing[1] * ; Li Shiyou[1] ; Xu Chen[1] ; Zhang Zhijie[1] ; Hua Ao[1] ; Ding Ze-Yang[2] ; Zhang Bi-Xiang[2] ; Yang Xiangliang[1,3,4,5,6,7] ; Li Zifu[1,4,5,6,7,*1] ;
单位： [1]National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China [2]Hepatic Surgery Center and Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China [3]GBA Research Innovation Institute for Nanotechnology, Guangdong 510530, PR China [4]Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China [5]Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China [6]Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, Huazhong University of Science and Technology, Wuhan 430074, PR China [7]Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan 430074, PR China
出处：
DOI： 10.1016/j.jconrel.2023.02.043
ISSN：

关键词： Hydroxyethyl starch Copper-diethyldithiocarbamate nanocrystal cancer stem cells Stabilization mechanism Reactive oxygen species cancer nanomedicine

摘要：
Cancer stem cells (CSCs) have been recognized as the culprit for tumor progression, treatment resistance, metastasis, and recurrence while redox homeostasis represents the Achilles' Heel of CSCs. However, few drugs or formulations that are capable of elevating oxidative stress have achieved clinical success for eliminating CSCs. Here, we report hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@HES NPs), which conspicuously suppress CSCs not only in vitro but also in numerous tumor models in vivo. Furthermore, CuET@HES NPs effectively inhibit CSCs in fresh tumor tissues surgically excised from hepatocellular carcinoma patients. Mechanistically, we uncover that hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals via copper‑oxygen coordination interactions, thereby promoting copper-diethyldithiocarbamate colloidal stability, cellular uptake, intracellular reactive oxygen species production, and CSCs apoptosis. As all components are widely used in clinics, CuET@HES NPs represent promising treatments for CSCs-rich solid malignancies and hold great clinical translational potentials. This study has critical implications for design of CSCs targeting nanomedicines.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
National Research and Development Program of China (2020YFA0211200, 2018YFA0208900, and 2020YFA0710700), the National Science Foundation of China (82172757, 31972927), the Scientific Research Foundation of Huazhong University of Science and Technology (3004170130), the Program for HUST Academic Frontier Youth Team (2018QYTD01), and the HCP Program for HUST
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药学 1 区 化学：综合
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药学 2 区 化学：综合
JCR分区：
出版当年[2021]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
共同第一作者：
通讯作者：
通讯机构： [1]National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China [4]Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China [5]Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China [6]Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, Huazhong University of Science and Technology, Wuhan 430074, PR China [7]Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan 430074, PR China [*1]Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, PR China
推荐引用方式(GB/T 7714)：
Xiao Chen,Li Jiayuan,Wang Xing,et al.Hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals for cancer therapy[J].JOURNAL OF CONTROLLED RELEASE.2023,356:288-305.doi:10.1016/j.jconrel.2023.02.043.
APA：
Xiao Chen,Li Jiayuan,Wang Xing,Li Shiyou,Xu Chen...&Li Zifu.(2023).Hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals for cancer therapy.JOURNAL OF CONTROLLED RELEASE,356,
MLA：
Xiao Chen,et al."Hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals for cancer therapy".JOURNAL OF CONTROLLED RELEASE 356.(2023):288-305

相关文献

[1]Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair [2]Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism [3]Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities [4]Carbon Monoxide Inhibits T Cell Proliferation by Suppressing Reactive Oxygen Species Signaling [5]S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats [6]Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain [7]Nox2 contributes to reactive oxygen species-induced redox imbalance in cancer-induced bone pain [8]SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species [9]Targeting the Main Sources of Reactive Oxygen Species Production: Possible Therapeutic Implications in Chronic Pain [10]Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma

资源点击量：426 今日访问量：2 总访问量：410 更新日期：2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有：重庆聚合科技有限公司 渝ICP备12007440号-3 地址：重庆市两江新区泰山大道西段8号坤恩国际商务中心16层（401121）