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SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species

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收录情况： ◇ SCIE

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单位： [1]Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, China. [2]Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [3]Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shangdong, China. [4]Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

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关键词： interaction mitochondria nucleocapsid ROS SARS‐CoV‐2

摘要：

Coronavirus disease 2019 (COVID-19) pathogenesis is influenced by reactive oxygen species (ROS). Nevertheless, the precise mechanisms implicated remain poorly understood. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the main driver for this condition, is a structural protein indispensable for viral replication and assembly, and its role in ROS production has not been reported. This study shows that SARS-CoV-2 N protein expression enhances mitochondrial ROS level. Bulk RNA-sequencing suggests of aberrant redox state of the electron transport chain. Accordingly, this protein hinders ATP production but simultaneously augments the activity of complexes I and III, and most mitochondrially encoded complex I and III proteins are upregulated by it. Mechanistically, N protein of SARS-CoV-2 shows significant mitochondrial localization. It interacts with mitochondrial transcription components and stabilizes them. Moreover, it also impairs the activity of antioxidant enzymes with or without detectable interaction.© 2023 Wiley Periodicals LLC.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区病毒学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区病毒学

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出版当年[2021]版：

Q1 VIROLOGY

最新[2023]版：

Q1 VIROLOGY

影响因子： 6.8 最新[2023版] 6.6 最新五年平均 20.693 出版当年[2021版] 12.203 出版当年五年平均 2.327 出版前一年[2020版] 12.7 出版后一年[2022版]

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第一作者单位： [1]Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species

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