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A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis

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收录情况： ◇ SCIE

作者：
Ren Ranyue[1] * ; Guo Jiachao[2] * ; Song Hao[3] ; Wei Yong[3] ; Luo Chao[3] ; Zhang Yayun[1] ; Chen Liangxi[1] ; Gao Biao[3] ; Fu Jijiang[3,*2] ; Xiong Wei[1,*1] ;
单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [2]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [3]The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, Wuhan, Hubei, China.
出处：
DOI： 10.1016/j.mtbio.2023.100590
ISSN：

关键词： Osseointegration Angiogenesis Osteoblastogenesis Fe3O4-Containing TiO2 nanorods Sinusoidal electromagnetic field Calcineurin

摘要：
Implants made of Ti and its alloys are widely utilized in orthopaedic surgeries. However, insufficient osseointegration of the implants often causes complications such as aseptic loosening. Our previous research discovered that disordered titanium dioxide nanorods (TNrs) had satisfactory antibacterial properties and biocompatibility, but TNrs harmed angiogenic differentiation, which might retarded the osseointegration process of the implants. Magnetic nanomaterials have a certain potential in promoting osseointegration, electromagnetic fields within a specific frequency and intensity range can facilitate angiogenic and osteogenic differentiation. Therefore, this study used Fe3O4 to endow magnetism to TNrs and explored the regulation effects of Ti, TNrs, and Fe3O4-TNrs under 1 ​mT 15 ​Hz sinusoidal electromagnetic field (SEMF) on osteoblastogenesis, osseointegration, angiogenesis, and its mechanism. We discovered that after the addition of SEMF treatment to VR-EPCs cultured on Fe3O4-TNrs, the calcineurin/NFAT signaling pathway was activated, which then reversed the inhibitory effect of Fe3O4-TNrs on angiogenesis. Besides, Fe3O4-TNrs with SEMF enhanced osteogenic differentiation and osseointegration. Therefore, the implant modification mode of Fe3O4-TNrs with the addition of SEMF could more comprehensively promote osseointegration and provided a new idea for the modification of implants.© 2023 The Authors.

基金：
This work was funded by National Natural Science Foundation of China (Nos. 82072405 and Nos. 81571816) and Scientific Research Foundation of Tongji Hospital (Nos. 2022B23)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 工程技术
小类 | 2 区 工程：生物医学 2 区 材料科学：生物材料
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 材料科学：生物材料 2 区 工程：生物医学
JCR分区：
出版当年[2021]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [3]The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, Wuhan, Hubei, China. [*1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Qiaokou District,Wuhan,430030,China [*2]The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, 947 Heping Avenue, Qingshan District, Wuhan, 430081, China
推荐引用方式(GB/T 7714)：
Ren Ranyue,Guo Jiachao,Song Hao,et al.A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis[J].MATERIALS TODAY BIO.2023,19:doi:10.1016/j.mtbio.2023.100590.
APA：
Ren Ranyue,Guo Jiachao,Song Hao,Wei Yong,Luo Chao...&Xiong Wei.(2023).A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis.MATERIALS TODAY BIO,19,
MLA：
Ren Ranyue,et al."A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis".MATERIALS TODAY BIO 19.(2023)

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