单位：[1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China华中科技大学同济医学院附属同济医院外科学系骨科[2]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China华中科技大学同济医学院附属同济医院儿科学系外科学系小儿外科[3]Department of Trauma and Reconstructive Surgery, Siegfried Weller Research Institute, BG Trauma Center Tübingen, University of Tübingen, Tübingen, Germany
The bone remodelling process is closely related to bone health. Osteoblasts and osteoclasts participate in the bone remodelling process under the regulation of various factors inside and outside. Excessive activation of osteoclasts or lack of function of osteoblasts will cause occurrence and development of multiple bone-related diseases. Ca2+/Calcineurin/NFAT signalling pathway regulates the growth and development of many types of cells, such as cardiomyocyte differentiation, angiogenesis, chondrogenesis, myogenesis, bone development and regeneration, etc. Some evidences indicate that this signalling pathway plays an extremely important role in bone formation and bone pathophysiologic changes. This review discusses the role of Ca2+/Calcineurin/NFAT signalling pathway in the process of osteogenic differentiation, as well as the influence of regulating each component in this signalling pathway on the differentiation and function of osteoblasts, whereby the relationship between Ca2+/Calcineurin/NFAT signalling pathway and osteoblastogenesis could be deeper understood.
基金：
National Natural Science Foundation of
China, Grant/Award Number: 81571816
and 82072405
第一作者单位：[1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China[*1]Department of Orthopedics,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China.
推荐引用方式(GB/T 7714)：
ranyue ren,jiachao guo,yangmengfan chen,et al.The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis[J].CELL PROLIFERATION.2021,54(11):e13122.doi:10.1111/cpr.13122.
APA：
ranyue ren,jiachao guo,yangmengfan chen,yayun zhang,liangxi chen&wei xiong.(2021).The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis.CELL PROLIFERATION,54,(11)
MLA：
ranyue ren,et al."The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis".CELL PROLIFERATION 54..11(2021)
生物学