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Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression

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资源类型：
作者：
Basu, A[a,c] * ; Liu, T[a,c,f] ; Banerjee, P[a,c] ; Flynn, E[a,c] ; Zurakowski, D[b,c] ; Datta, D[a,c,g] ; Viklicky, O[d] ; Gasser, M[e] ; Waaga-Gasser, A.M[e] ; Yang, J[a,c,h] ; Pal, S[a,c] ;
单位： [a]Division of Nephrology and Transplantation Research Center, Boston, MA, United States [b]Department of Anesthesia, Children's Hospital, Boston, MA, United States [c]Harvard Medical School, Boston, MA, United States [d]Transplant Center, Institute of Clinical and Experimental Medicine, Prague, Czech Republic [e]Department of Surgery I, Molecular Oncology and Immunology, University of Wurzburg, Wurzburg, Germany [f]Department of Cancer Biology, MD Anderson Cancer Center, TX, United States [g]Central Drug Research Institute, Lucknow, India [h]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1016/j.canlet.2012.02.004
ISSN：

关键词： Angiogenesis Chemokine Renal cancer Transplantation VEGF

摘要：
Calcineurin inhibitors (CNIs) may promote post-transplantation cancer through altered expression of cytokines and chemokines in tumor cells. We found that there is a potential cross-talk among CNI-induced signaling molecules and mTOR. Here, we utilized a murine model of post-transplantation cancer to examine the effect of a combination therapy (CNI. +. mTOR-inhibitor rapamycin) on allograft survival and renal cancer progression. The therapy prolonged allograft survival; and significantly attenuated CNI-induced post-transplantation cancer progression, with down-regulation of mTOR and S6-kinase phosphorylation. Also, rapamycin inhibited CNI-induced over-expression of the angiogenic cytokine VEGF, and the chemokine receptor CXCR3 and its ligands in post-transplantation tumor tissues. © 2012 Elsevier Ireland Ltd.

基金：
We wish to thank Dr. Mohamed H. Sayegh for helpful suggestion about this work. This work was supported by National Institutes of Health Grant R01 CA131145 (to S. P.).
语种：
外文
中科院(CAS)分区：
出版当年[2011]版：
大类 | 2 区 医学
小类 | 3 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
第一作者：
第一作者单位： [a]Division of Nephrology and Transplantation Research Center, Boston, MA, United States [c]Harvard Medical School, Boston, MA, United States
通讯作者：
通讯机构： [a]Division of Nephrology and Transplantation Research Center, Boston, MA, United States [c]Harvard Medical School, Boston, MA, United States
推荐引用方式(GB/T 7714)：
Basu A,Liu T,Banerjee P,et al.Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression[J].Cancer Letters.2012,321(2):doi:10.1016/j.canlet.2012.02.004.
APA：
Basu, A,Liu, T,Banerjee, P,Flynn, E,Zurakowski, D...&Pal, S.(2012).Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression.Cancer Letters,321,(2)
MLA：
Basu, A,et al."Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression".Cancer Letters 321..2(2012)

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