单位：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.口腔科华中科技大学同济医学院附属同济医院[2]Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
Periodontal disease (PD) is one of the most common infectious diseases with complex inflammatory conditions, having irreversibly destructive impacts on the periodontal supporting tissues. The application of cold atmospheric plasma (CAP) is a promising adjuvant therapy modality for PD. However, the mechanism of CAP in PD treatment is still poorly understood. The review motivates to outline the latest research concerning the applications of CAP in PD treatment.We searched CAP-related literature utilizing the well-established databases of Pubmed, Scopus and Web of Science according to the following keywords related to periodontal disease (periodontal, gingival, gingivitis, gingiva, periodontium, periodontitis).A total of 18 concerning original studies were found. These studies could be classified according to three pathophysiological perspectives of PD. The therapeutic mechanisms of CAP may be attributed to the oxidative stress-related cell death of periodontal bacteria, the suppression of periodontal inflammation and pro-inflammatory cytokine secretion, as well as the acceleration of periodontal soft tissue wound healing and hard tissue reconstruction.CAP has potential therapeutic effects on PD through three mechanisms: antimicrobial effect, inflammation attenuation, and tissue remodeling. This review hopefully provides a comprehensive perspective into the potential of CAP in PD therapy.This article is protected by copyright. All rights reserved.
基金：
Key R & D Program of National Natural Science
Foundation of China (82170933), Hubei Province of China (2020BCB057) and the Hubei
Province health and family planning scientific research project (WJ2023M009).
第一作者单位：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[2]Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
通讯作者：
通讯机构：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[2]Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.[*1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, China, 430030
推荐引用方式(GB/T 7714)：
Liu Zhixin,Du Xijin,Xu Lianyi,et al.The Therapeutic Perspective of Cold Atmospheric Plasma in Periodontal Disease[J].ORAL DISEASES.2023,doi:10.1111/odi.14547.
APA：
Liu Zhixin,Du Xijin,Xu Lianyi,Shi Qi,Tang Xuezhi...&Song Ke.(2023).The Therapeutic Perspective of Cold Atmospheric Plasma in Periodontal Disease.ORAL DISEASES,,
MLA：
Liu Zhixin,et al."The Therapeutic Perspective of Cold Atmospheric Plasma in Periodontal Disease".ORAL DISEASES .(2023)
