单位：[1]State Key Lab of Advanced Electromagnetic Engineering and Technology, School of Electronic and Electrical Engineering, Huazhong University of Science and Technology, Wuhan, China[2]Wuhan National High Magnetic Field Center, Wuhan, China[3]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China口腔科华中科技大学同济医学院附属同济医院[4]School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Recently, the cold atmospheric plasma (CAP) has demonstrated a satisfactory ability to inactivate severe acute respiratory syndrome CoV-2 (SARS-CoV-2), but the microscopic inactivation mechanism is still unclear. This paper takes the interaction process between O atoms generated by plasma and the spike protein of coronavirus as the research object. It uses the reaction molecular dynamics simulation method to study the reaction mechanism of different numbers of O atoms and the spike protein molecules. The results show that the O atom triggers a chain reaction by taking away hydrogen atoms in the spike protein molecule, destroying the molecular structure of the spike protein and making it inactive. The severity of the reaction and the destruction of the spike protein molecule also increases with increasing O atom numbers.
基金：
National Natural Science Foundation of China [52277149, 81701035]; Interdisciplinary Program of Wuhan National High Magnetic Field Center [WHMFC202144]; Huazhong University of Science and Technology
第一作者单位：[1]State Key Lab of Advanced Electromagnetic Engineering and Technology, School of Electronic and Electrical Engineering, Huazhong University of Science and Technology, Wuhan, China
通讯作者：
通讯机构：[1]State Key Lab of Advanced Electromagnetic Engineering and Technology, School of Electronic and Electrical Engineering, Huazhong University of Science and Technology, Wuhan, China[2]Wuhan National High Magnetic Field Center, Wuhan, China[3]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China[4]School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China[*1]State Key Lab of Advanced Electromagnetic Engineering and Technology, School of Electronic and Electrical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China[*2]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
推荐引用方式(GB/T 7714)：
Yang Zihao,Xiao Ao,Liu Dawei,et al.Damage of SARS-CoV-2 spike protein by atomic oxygen of cold atmospheric plasma: A molecular dynamics study[J].PLASMA PROCESSES AND POLYMERS.2023,20(7):doi:10.1002/ppap.202200242.
APA：
Yang, Zihao,Xiao, Ao,Liu, Dawei,Shi, Qi&Li, Yan.(2023).Damage of SARS-CoV-2 spike protein by atomic oxygen of cold atmospheric plasma: A molecular dynamics study.PLASMA PROCESSES AND POLYMERS,20,(7)
MLA：
Yang, Zihao,et al."Damage of SARS-CoV-2 spike protein by atomic oxygen of cold atmospheric plasma: A molecular dynamics study".PLASMA PROCESSES AND POLYMERS 20..7(2023)
