单位：[1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.神经内科神经科华中科技大学同济医学院附属同济医院[2]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.检验科华中科技大学同济医学院附属同济医院
A growing body of evidence suggests immune involvement in the pathology of multiple system atrophy (MSA). Research on detailed peripheral immune indices, however, is relatively sparse, and is one of the intriguing aspects of MSA yet to be elucidated. A total of 26 MSA patients and 56 age-and sex-matched healthy controls (HC) were enrolled in the current case-control study to delineate the peripheral immune traits of MSA patients. The ratio of CD4+/CD8+ T cells, natural killer cells, CD28 expression on both CD4+ T cells and CD8+ T cells increased in MSA patients compared to HC, but CD8+ T cells and active marker (HLA-DR) expression on total T cells decreased (p < 0.05). This study sheds light on the dysregulation of cellular immunity in MSA, pointing to future mechanistic research.
基金：
National Natural Science Foundation of China (No. 82271478).
第一作者单位：[1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Gong Zhenxiang,Gao Rong,Ba Li,et al.The Peripheral Immune Traits Changed in Patients with Multiple System Atrophy[J].BRAIN SCIENCES.2023,13(2):doi:10.3390/brainsci13020205.
APA：
Gong Zhenxiang,Gao Rong,Ba Li,Liu Yang,Hou Hongyan&Zhang Min.(2023).The Peripheral Immune Traits Changed in Patients with Multiple System Atrophy.BRAIN SCIENCES,13,(2)
MLA：
Gong Zhenxiang,et al."The Peripheral Immune Traits Changed in Patients with Multiple System Atrophy".BRAIN SCIENCES 13..2(2023)
