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Sirtuins functions in central nervous system cells under neurological disorders

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan, Peoples R China [2]Sun Yat Sen Univ, Canc Ctr, Dept Anesthesiol, Guangzhou, Peoples R China

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关键词： sirtuins central nervous syste neuron microglia astrocyte oligodendrocyte

摘要：

The sirtuins (SIRTs), a class of NAD+ -dependent deacylases, contain seven SIRT family members in mammals, from SIRT1 to SIRT7. Extensive studies have revealed that SIRT proteins regulate virous cell functions. Central nervous system (CNS) decline resulted in progressive cognitive impairment, social and physical abilities dysfunction. Therefore, it is of vital importance to have a better understanding of potential target to promote homeostasis of CNS.SIRTs have merged as the underlying regulating factors of the process of neurological disorders. In this review, we profile multiple functions of SIRT proteins in different cells during brain function and under CNS injury

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 2 区生理学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区生理学

JCR分区：

出版当年[2020]版：

Q1 PHYSIOLOGY

最新[2023]版：

Q2 PHYSIOLOGY

影响因子： 3.2 最新[2023版] 4 最新五年平均 4.566 出版当年[2020版] 4.805 出版当年五年平均 3.367 出版前一年[2019版] 4.755 出版后一年[2021版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan, Peoples R China

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