High-performance strain sensors have received extensive attention due to their wide range of applications in pulsebeat detection, speech recognition, motion detection, and blood pressure monitoring. However, it is difficult to simultaneously attain high sensitivity and excellent stretchability. In this work, a strain sensor based on modified polydimethylsiloxane (PDMS) and conductive hybrid particles of silver nanowires (AgNWs)/graphene was successfully fabricated. A facile solvothermal polymerization process was used to change the structure of cross-linking networks and to obtain the PDMS elastomer with excellent stretchability. The application of the modified PDMS endows the strain sensor with a large strain range (∼20%), which is 100% higher than that of the strain sensor with unmodified PDMS. The AgNWs/graphene hybrid particles were prepared by a simple coprecipitation, reduction, and drying method. AgNWs serve as bridges between graphene sheets, endowing the strain sensor with a large gauge factor (GF = 400). The stability of the strain sensor was also verified. Besides, the strain sensor was successfully used in fields such as finger bending and speech recognition. Considering its high sensitivity, excellent stretchability, and high working stability, the sensor has great potential in health monitoring and motion detection.© 2022 IOP Publishing Ltd.