单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan, Peoples R China妇产科学系计划生育专科华中科技大学同济医学院附属同济医院[2]Wuhan Huchuang Union Technol Co Ltd, Wuhan, Hebei, Peoples R China
Polar bodies are tiny cells that are extruded during oocyte meiosis and are generally considered not essential for embryonic development. Therefore, polar bodies have been widely used as important materials for the preimplantation genetic diagnosis of human embryos. Recent studies have shown that polar bodies mediate embryonic development and that their morphology is related to embryo quality and developmental potential. However, the relationship between the emission of the polar body and embryonic euploidy remains unclear. In this study, a total of 1,360 blastocyst trophectoderm (TE) biopsies were performed, and blastocyst ploidy results were correlated with the state of polar bodies. The results showed that polar body angle size and polar body status are not directly related to whether the blastocysts are euploid, aneuploid, or mosaic (p > 0.05). Therefore, in the process of clinical embryo selection, embryologists should not predict the euploidy of blastocysts based on the state of polar bodies, thus affecting embryo selection.
基金：
National Key Research & Development Program of China; [2021 YFC2700603]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Yongle,Tan Wei,Chen Changsheng,et al.Correlation of the position and status of the polar body from the fertilized oocyte to the euploid status of blastocysts[J].FRONTIERS IN GENETICS.2022,13:doi:10.3389/fgene.2022.1006870.
APA：
Yang, Yongle,Tan, Wei,Chen, Changsheng,Jin, Lei&Huang, Bo.(2022).Correlation of the position and status of the polar body from the fertilized oocyte to the euploid status of blastocysts.FRONTIERS IN GENETICS,13,
MLA：
Yang, Yongle,et al."Correlation of the position and status of the polar body from the fertilized oocyte to the euploid status of blastocysts".FRONTIERS IN GENETICS 13.(2022)
