The purpose of this study was to treat UiO-66 (University of Oslo 66) under suitable thermal alkaline hydrolysis condition to realize the loading of gallic acid. UiO-66-SH (UiO-66-separated-heating) was obtained by separated heating UiO-66 and 0.2 M KOH aqueous solution to 120 degrees C before mixing for 3 h. The material was in an amorphous state, maintained the octahedron structure and size of UiO-66. UiO-66-SH has better porosity and specific surface area than UiO-66, and had good thermal stability until heated to 1000 degrees C. Furthermore, UiO-66SH had very little influence of the cellular activity of human normal heptical cell line, demonstrating its good biocompatibility. The prepared UiO-66-SH could successfully adsorb gallic acid and control the release of gallic acid in simulated gastric fluid (-58% vs. - 88% of free gallic acid). This study will be conducive to preparation of appropriate carrier used to load with polyphenolic compounds such as gallic acid.
基金：
Shanxi Province Science Foundation for Youths [20210302124190, 201801D221406]
第一作者单位：[1]Shanxi Med Univ, Sch Pharm, Taiyuan 030001, Peoples R China
通讯作者：
通讯机构：[3]Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3,Dept Pharm, Taiyuan 030032, Peoples R China[4]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Chang Rui-Miao,Zhang Yan-Yang,Zhang Guang-Bin,et al.Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66[J].FOOD CHEMISTRY.2022,391:doi:10.1016/j.foodchem.2022.133238.
APA：
Chang, Rui-Miao,Zhang, Yan-Yang,Zhang, Guang-Bin,Zhang, Xiao-Xia,Chen, An-Jia...&Li, Yong.(2022).Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66.FOOD CHEMISTRY,391,
MLA：
Chang, Rui-Miao,et al."Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66".FOOD CHEMISTRY 391.(2022)
农林科学