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Bone morphogenetic proteins induce rabbit bone marrow-derived mesenchyme stem cells to differentiate into osteoblasts via BMP signals pathway

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收录情况： ◇ SCIE

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单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,P.R. China

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关键词： bone marrow BMP signals pathway MSCs osteoblast

摘要：

Bone marrow mesenchymal stem cells (BMMSCs) are multipotent stem cells that can differentiate into different blastoderm cells in vitro. In this study, BMMSCs in rabbit bone marrow were isolated by density gradient centrifuge separation, purified and expanded in vitro. BMP-2 and FGF 2 were used for differentiation into osteoblasts, and the results demonstrated that bone morphogenetic proteins (BMPs) could affect the differential direction of the BMMSCs. PCR assays indicated that BMP signals pathway played important roles in osteoblasts differentiation of BMMSCs, and the members included BMPRI, Smad 1, Smad 5, Smad 8, Runx 2, collage type I and osteopontin. This study provides a theoretical basis and experimental evidence for the therapeutic application of BMMSCs to the treatment of bone injury.

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最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生物工程与应用微生物 3 区工程：生物医学 3 区材料科学：生物材料

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出版当年[2011]版：

无

最新[2023]版：

Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ENGINEERING, BIOMEDICAL Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 4.5 最新[2023版] 5.1 最新五年平均 0 出版当年[2011版] 0 出版当年五年平均 0 出版前一年[2010版]

第一作者：

第一作者单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,P.R. China

通讯作者：

通讯机构： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,P.R. China [*1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan,P.R. China

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