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Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers

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收录情况： ◇ SCIE

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单位： [1]Anhui Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Hefei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Ctr Med Expt, Wuhan, Peoples R China [3]Friedrich Schiller Univ Jena, Expt Transplantat Surg, Dept Gen Visceral & Vasc Surg, Jena, Germany

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关键词： inflammation single nucleotide polymorphisms lipopolysaccharide-binding protein infections inflammatory diseases metabolic disorders cancers

摘要：

Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.

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出版当年[2020]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2019]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 5.085 出版当年[2019版] 5.733 出版当年五年平均 4.716 出版前一年[2018版] 7.561 出版后一年[2020版]

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第一作者单位： [1]Anhui Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Hefei, Peoples R China

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