There has been no report investigating the role of IL-38 in inflammatory bowel diseases (IBD). Therefore, we investigated the expression of IL-38 in IBD patients and its role in regulating intestinal inflammation. The levels of IL-38 were significantly elevated in the intestine of IBD patients and DSS-induced colitis mice. Immunofluorescence analysis revealed that B cell, not macrophage or T cell, was the source of IL-38 in the intestine. We found that rIL-38 treatment significantly attenuated DSS-induced colitis, including alleviation of weight loss, disease activity index, macroscopic changes and histological damage of colon, along with lower levels of IL-1 beta and TNF-alpha. In vitro, rIL-38 significantly decreased the expression of proinflammatory cytokines in LPS-stimulated RAW 264.7 cells and BMDM. This is the first study suggesting that IL-38 may have a protective effect in IBD, which inhibits the production of proinflammatory cytokines from macrophages. IL-38 may represent a promising therapeutic strategy in IBD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570501, 81770554, 81772607, 81700490]
第一作者单位：[1]Huazhong Univ Sci & Technol, Union Hosp, Dept Gastroenterol, Tongji Med Coll, 1277 Jiefang Rd, Wuhan 430022, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xie Cheng,Yan Wei,Quan Runze,et al.Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation[J].CYTOKINE.2020,127:doi:10.1016/j.cyto.2019.154963.
APA：
Xie, Cheng,Yan, Wei,Quan, Runze,Chen, Chaoyue,Tu, Lei...&Fu, Yu.(2020).Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation.CYTOKINE,127,
MLA：
Xie, Cheng,et al."Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation".CYTOKINE 127.(2020)
