单位:[1]Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院大内科内科学系心血管内科[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院内科学系心血管内科
Despite mounting evidence demonstrating the significance of inflammation in the pathophysiological mechanisms of heart failure (HF), most large clinical trials that target the inflammatory responses in HF yielded neutral or even worsening outcomes. Further in-depth understanding about the roles of inflammation in the pathogenesis of HF is eagerly needed. This review summarizes cytokines, cardiac infiltrating immune cells, and extracardiac organs that orchestrate the complex inflammatory responses in HF and highlights emerging therapeutic targets.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91839302, 81630010, 81790624]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2020CFA016]; Tongji Hospital Clinical Research Flagship Program [2019CR207]
第一作者单位:[1]Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
通讯作者:
通讯机构:[1]Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
推荐引用方式(GB/T 7714):
Li Huihui,Chen Chen,Wang Dao Wen.Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure[J].FRONTIERS IN PHYSIOLOGY.2021,12:doi:10.3389/fphys.2021.695047.
APA:
Li,Huihui,Chen,Chen&Wang,Dao Wen.(2021).Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure.FRONTIERS IN PHYSIOLOGY,12,
MLA:
Li,Huihui,et al."Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure".FRONTIERS IN PHYSIOLOGY 12.(2021)