单位：[1]The Center for Biomedical Research,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院生物医学研究中心生物医学中心科研平台[2]Department of Rehabilitation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院康复医学科[3]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院外科学系骨科
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82072556]
第一作者单位：[1]The Center for Biomedical Research,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
通讯作者：
推荐引用方式(GB/T 7714)：
luo jiahui,xu tao,sun kai.N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2021,9:doi:10.3389/fcell.2021.670711.
APA：
luo,jiahui,xu,tao&sun,kai.(2021).N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9,
MLA：
luo,jiahui,et al."N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9.(2021)
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