详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Epigenetic Modification of m6A Methylation: Regulatory Factors, Functions and Mechanism in Inflammatory Bowel Disease

67| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [2]Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

出处：

DOI：

ISSN：

关键词： Inflammatory bowel disease (IBD) Epigenetic N6-methyladenosine (m6A)

摘要：

Although the exact cause of inflammatory bowel disease (IBD) is still unknown, there is a lot of evidence to support the notion that it results from a combination of environmental factors, immune system issues, gut microbial changes, and genetic susceptibility. In recent years, the role of epigenetics in the pathogenesis of IBD has drawn increasing attention. The regulation of IBD-related immunity, the preservation of the intestinal epithelial barrier, and autophagy are all significantly influenced by epigenetic factors. The most extensive epigenetic methylation modification of mammalian mRNA among them is N-6-methyladenosine (m6A). It summarizes the general structure and function of the m6A regulating factors, as well as their complex effects on IBD by regulating the intestinal mucous barrier, intestine mucosal immunity, epidermal cell death, and intestinal microorganisms.This paper provides key insights for the future identification of potential new targets for the diagnosis and treatment of IBD.Copyright © 2023 Elsevier Ltd. All rights reserved.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2022]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3.4 最新[2023版] 4.3 最新五年平均 4 出版当年[2022版] 4.5 出版当年五年平均 5.652 出版前一年[2021版] 3.4 出版后一年[2023版]

第一作者：

第一作者单位： [1]Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [2]Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [*1]Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430022, Hubei, China. [*2]Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis [2]Comprehensive analysis of m6A modification patterns and m6A-related lncRNAs as potential biomarkers in lung adenocarcinoma [3]Dynamic role of macrophage CX3CR1 expression in inflammatory bowel disease [4]Electroacupuncture inhibits visceral pain via adenosine receptors in mice with inflammatory bowel disease [5]Article Inflammatory bowel disease is associated with worse sexual function: a systematic review and meta-analysis [6]IRF/Type I IFN signaling serves as a valuable therapeutic target in the pathogenesis of inflammatory bowel disease [7]Identification and Validation of 7-lncRNA Signature of Epigenetic Disorders by Comprehensive Epigenetic Analysis [8]胆管癌表观遗传学研究进展 [9]支气管肺发育不良的表观遗传学机制研究进展 [10]Single-Stranded RNA Origami-Based Epigenetic Immunomodulation