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Thrombogenic polymer surface manipulation of microlfuidic chips via ultraviolet laser

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单位： [a]School of Mechanical Science and Engineering,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,China [b]Experimental Medicine Center,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,China [c]Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, China

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关键词： Hemodynamic study High wettability contrast patterns Microfluidic chips Platelet adhesion and aggregation Platelet-surface interaction

摘要：

The study of platelet adhesion and aggregation to biomaterial surfaces provides an efficient way for thrombogenicity diagnosis. Herein, we introduced a one-step, cost-effective strategy for fast fabrication of patterned extreme wettability contrast from superhydrophilic to superhydrophobic for the polymer surface manipulation. The study of platelet interaction in controllable conditions can be facilitated within a microfluidic chip. In-vitro testing indicates that both micro-topography and wettability of channel surface are important factors for fabricating blood compatibility and high thrombogenic surface, which may contribute to implantable or hemostatic materials. It is expected that this facile approach is promising to apply for biological, medical and diagnostic purposes. © 2020 CBMS-0001

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第一作者单位： [a]School of Mechanical Science and Engineering,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,China

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