单位：[1]School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China[2]The First School of Clinical Medicine, Health Science Center, Yangtze University, Nanhuan Road, Jingzhou, Hubei 434023k, China[3]SingHealth Internal Medicine Residency Programme, Singapore General Hospital, 169608, Singapore[4]Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore[5]School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[6]Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, PR China.[7]Cancer Science Institute of Singapore, National University of Singapore, Singapore[8]Department of Haematology-Oncology, National University Cancer Institute, Singapore, 1E Lower Kent Ridge Road, National University Health System Tower Block Level 7, Singapore 119228
Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it governs the metastatic potential of multiple primary cancers. It is also potentially involved in the regulation of tumorigenesis, tumor metabolism, and proangiogenic activity. A wealth of clinical data across a wide range of cancer types has revealed strong correlations between hypoxia or the overexpression of hypoxia-inducible transcription factors and the rates of distal metastases and poor prognoses. HIF-1α, one of the key regulatory molecules of the HIF-1 signaling pathways, is involved in multiple crucial steps in the metastatic cascade. Here, we present recent findings on the roles of the HIF-1 complex in tumor metastasis and consider the potential of HIF-1α as a target for abrogating tumor metastasis. Moreover, we systematically describe the regulatory role of HIF-1 at each step of the metastatic cascade. Finally, we present the most recent advances in potential pharmacological interventions and the development of specific HIF-1 inhibitors for blocking tumor metastasis.
基金：
This work was supported by grants from the Natural Science Foundation of Hubei Province (2019CFB591 to Z.M.), Central Funds Guiding the Local Science and Technology Development of Hubei Province (2019ZYYD066 to Q.G.). This work was also funded to Boon Cher Goh by the Singapore Ministry of Health’s National Medical Research Council, the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiatives. This work was also supported by NUHS Seed Grant to GS.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区生物
小类|2 区生化与分子生物学2 区内分泌学与代谢
最新[2025]版：
大类|2 区生物学
小类|2 区生化与分子生物学2 区内分泌学与代谢
第一作者：
第一作者单位：[1]School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China[2]The First School of Clinical Medicine, Health Science Center, Yangtze University, Nanhuan Road, Jingzhou, Hubei 434023k, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China[2]The First School of Clinical Medicine, Health Science Center, Yangtze University, Nanhuan Road, Jingzhou, Hubei 434023k, China[4]Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore[*1]School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China[*2]Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600
推荐引用方式(GB/T 7714)：
Zhaowu Ma,Louis ZizhaoWang,Jun-Ting Cheng,et al.Targeting HIF-1-mediated Metastasis for Cancer Therapy.[J].Antioxidants & redox signaling.2020,doi:10.1089/ars.2019.7935.
APA：
Zhaowu Ma,Louis ZizhaoWang,Jun-Ting Cheng,Walter Sze Tung Lam,Xiang Ma...&Lingzhi Wang.(2020).Targeting HIF-1-mediated Metastasis for Cancer Therapy..Antioxidants & redox signaling,,
MLA：
Zhaowu Ma,et al."Targeting HIF-1-mediated Metastasis for Cancer Therapy.".Antioxidants & redox signaling .(2020)
生物学