Sepsis-associated acute lung injury (ALI) is a clinically critical disease that carries a high mortality rate. The pathogenesis of sepsis-associated ALI has not yet been precisely elucidated and there is a lack of effective treatment. As a new endogenous docosahexaenoic acid (DHA)-derived lipid mediators, Maresin1 has a significant dual role of anti-inflammatory and promoting inflammation regression. In this study, we established the sepsis model by the cecal ligation and puncture method (CLP) to explore the effect of Maresin1 on sepsis-induced lung injury. We found that the intervention of Maresin1 could significantly attenuate the sepsis-induced inflammatory responses, characterized by the down-regulation of the level of IL-1 beta, IL-6, TNF-alpha, MPO, etc. Maresin1 could also significantly decrease the number of neutrophils in lung tissue, thus improving the related lung injury indicators. Our experiment clarified that the protective effect of Maresin1 on sepsis-associated lung injury is closely related to its inhibition function of JAK2/STAT3 and MAPK/NF-KB signaling pathways. Our findings provide new research directions and therapeutic targets for sepsis-associated ALI.
基金：
National Natural Science Foundation of China [81701887, 81671890]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesiol, Wuhan 430022, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Inst Anesthesia & Crit Care Med, Wuhan 430022, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesiol, Wuhan 430022, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Inst Anesthesia & Crit Care Med, Wuhan 430022, Peoples R China[*1]Huazhong Univ Sci & Technol, Inst Anesthesia & Crit Care Med, Tongji Med Coll, Dept Anesthesiol,Union Hosp, 1277 Jiefang Ave, Wuhan 430022, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Fuquan,Wang Min,Wang Jingxu,et al.Maresin1 ameliorates sepsis-associated lung injury by inhibiting the activation of the JAK2/STAT3 and MAPK/NF-κB signaling pathways[J].MICROBIAL PATHOGENESIS.2020,148:doi:10.1016/j.micpath.2020.104468.
APA：
Wang, Fuquan,Wang, Min,Wang, Jingxu,Chen, Ming,Sun, Shujun...&Xia, Haifa.(2020).Maresin1 ameliorates sepsis-associated lung injury by inhibiting the activation of the JAK2/STAT3 and MAPK/NF-κB signaling pathways.MICROBIAL PATHOGENESIS,148,
MLA：
Wang, Fuquan,et al."Maresin1 ameliorates sepsis-associated lung injury by inhibiting the activation of the JAK2/STAT3 and MAPK/NF-κB signaling pathways".MICROBIAL PATHOGENESIS 148.(2020)
