Endothelial progenitor cells (EPCs) could function as niche cells to promote self-renewal of mesenchymal stem cells (MSCs) in the mouse bone marrow. Cohesion was the basis of the two cells to display their biological functions to each other. In this study, we investigated the mechanism of cohesion between MSCs and EPCs. And demonstrated that fibronectin (FN) in EPCs activated the integrin alpha 5 beta 1 of MSCs and further mediated cell-cell cohesion. Integrin alpha 5 beta 1 and its FN ligand played critical roles not only in single-cell line adhesion, but also in adhesion between stem and niche cells. This novel finding is important to understand the cross-talk between MSCs and their niche cells.
基金：
national natural science foundation of China [31271458]; science and technology program of Xinjiang production and construction corps [2014AB047]; scientific research foundation for the returned overseas Chinese scholars, ministry of human resources and social security of the people's republic of China [RSLX201201]; Shihezi university youth science and technology research and development program, basis and application research project [20142RKXYQ20]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Sch, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China[2]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi 832008, Xinjiang, Peoples R China
通讯作者：
通讯机构：[2]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi 832008, Xinjiang, Peoples R China[*1]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, North 2th Rd, Shihezi 832008, Xinjiang, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang H. W.,Chen X. L.,Lin Z. Y.,et al.Fibronectin chorused cohesion between endothelial progenitor cells and mesenchymal stem cells of mouse bone marrow[J].CELLULAR AND MOLECULAR BIOLOGY.2015,61(2):26-32.doi:10.14715/cmb/2015.61.2.5.
APA：
Zhang, H. W.,Chen, X. L.,Lin, Z. Y.,Xia, J.,Hou, J. X....&Wu, X. W..(2015).Fibronectin chorused cohesion between endothelial progenitor cells and mesenchymal stem cells of mouse bone marrow.CELLULAR AND MOLECULAR BIOLOGY,61,(2)
MLA：
Zhang, H. W.,et al."Fibronectin chorused cohesion between endothelial progenitor cells and mesenchymal stem cells of mouse bone marrow".CELLULAR AND MOLECULAR BIOLOGY 61..2(2015):26-32
