Stem cells dwell at the "stem cell niche" to accomplish a series of biological processes. The composition of the niche should be determined because the insufficient understanding of this feature limits the development in the study of stem cells. We showed in our study on mesenchymal stem cells (MSCs) that the MSCs first neighbored to CD31(+) cells, which proved to be endothelial progenitor cells (EPCs), and formed a group of cell colony before they exerted their biological functions. It was further proved that EPCs have close interactions with MSCs and promoted the self-renewal of the MSCs in vitro and in vivo. Together with these achievements, we hypothesized that EPCs may be a possible biological component of the MSC stem cell niche and affect the biological processes of MSCs.
基金：
National Natural Science Foundation of China [31271458]; Science and Technology Program of Xinjiang Production and Construction Corps [2011AB034, 2014AB047]; Scientific Research Foundation for the returned overseas Chinese scholars, Ministry of Human Resources and Social Security of the People's Republic of China [RSLX201201]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Sch, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China[2]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi 832008, Xinjiang, Peoples R China
通讯作者：
通讯机构：[2]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi 832008, Xinjiang, Peoples R China[*1]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, North 2th Rd, Shihezi 832008, Xinjiang, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Hongwei,Xian Lingling,Lin Zhiyi,et al.Endothelial progenitor cells as a possible component of stem cell niche to promote self-renewal of mesenchymal stem cells[J].MOLECULAR AND CELLULAR BIOCHEMISTRY.2014,397(1-2):235-243.doi:10.1007/s11010-014-2191-3.
APA：
Zhang, Hongwei,Xian, Lingling,Lin, Zhiyi,Yang, Chaozhe,Zhang, Meng...&Wu, Xiangwei.(2014).Endothelial progenitor cells as a possible component of stem cell niche to promote self-renewal of mesenchymal stem cells.MOLECULAR AND CELLULAR BIOCHEMISTRY,397,(1-2)
MLA：
Zhang, Hongwei,et al."Endothelial progenitor cells as a possible component of stem cell niche to promote self-renewal of mesenchymal stem cells".MOLECULAR AND CELLULAR BIOCHEMISTRY 397..1-2(2014):235-243
