Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, including the retina, and play an important role in both regulating neurogenesis and neural stem cell proliferation. GABAa receptor has been identified in the retina, however, the function of GABAa receptor on retinal progenitor cell (RPC) is unclear. RPCs were cultured to analyze changes in cell proliferation and cell cycle distribution after GABAa receptor activation. The activation of GABAa receptor significantly inhibits RPCs proliferation, cell cycle progress, and self-renewal. Moreover, the activation of GABAa receptor leads to the up-expression of p21 and p27 and down-expression of Nestin, Pax6, Sox2, and Chx10. These results suggest that GABA acts as a negative regulator of RPCs proliferation and self-renewal.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 81501090, 81701476]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M613396]; National Key Research and Development Program [2018YFA0107303]; National Key Basic Research Program of ChinaNational Basic Research Program of China [2013CB967001]
第一作者单位：[1]Chinese Peoples Liberat Army, Gen Hosp, Dept Ophthalmol, Beijing 100853, Peoples R China[2]Acad Mil Med Sci, Dept Ophthalmol, Affiliated Hosp, Beijing 100071, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Shaojun,Du Lu,Peng Guanghua,et al.GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell[J].CELL DEATH DISCOVERY.2019,5:doi:10.1038/s41420-019-0160-z.
APA：
Wang, Shaojun,Du, Lu,Peng, Guanghua&Li, Wei.(2019).GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell.CELL DEATH DISCOVERY,5,
MLA：
Wang, Shaojun,et al."GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell".CELL DEATH DISCOVERY 5.(2019)
生物学