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Alteration of circadian rhythm during epileptogenesis: implications for the suprachiasmatic nucleus circuits.

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单位： [1]department of ophthalmology,tongji hospital,tongji medical college,huazhong university of science and technologywuhan 430030,hubei,china. [2]department of anesthesiology and pain medicine,tongji hospital of tongji medical college,huazhong university of science and technologywuhan 430030,hubei,pr china. [3]intensive care unit,wuhan medical treatment centerno. 1 yintan road,dongxihu district,wuhan 430023,pr china. [4]department of anesthesiology,liyuan hospital of tongji medical college,huazhong university of science & technologywuhan 430077,hubei province,china.

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关键词： Circadian rhythm Epileptic seizures Neural crosstalk Suprachiasmatic nucleus

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It is important to realize that characterization of the circadian rhythm patterns of seizure occurrence can implicate in diagnosis and treatment of selected types of epilepsy. Evidence suggests a role for the suprachiasmatic nucleus (SCN) circuits in overall circadian rhythm and seizure susceptibility both in animals and humans. Thus, we conclude that SCN circuits may exert modifying effects on circadian rhythmicity and neuronal excitability during epileptogenesis. SCN circuits will be studied in our brain centre and collaborating centres to explore further the interaction between the circadian rhythm and epileptic seizures. More and thorough research is warranted to provide insight into epileptic seizures with circadian disruption comorbidities such as disorders of cardiovascular parameters and core body temperature circadian rhythms.

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第一作者单位： [1]department of ophthalmology,tongji hospital,tongji medical college,huazhong university of science and technologywuhan 430030,hubei,china.

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