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SIX4 promotes metastasis through STAT3 activation in breast cancer.

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单位： [1]Department of GI Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China. [2]Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University Shihezi 832000, Xinjiang, P. R. China. [3]Department of Pathology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, Xinjiang, P. R. China. [4]Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China.

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关键词： SIX4 metastasis STAT3 breast cancer

摘要：

Sine oculis homeobox homolog 4 (SIX4), a member of the SIX family, play important role in the development and construction of vertebrate tissues and organs. There is very little known about the function of SIX4 in cancer cells. Herein, we investigated whether SIX4 promote cancer metastasis in addition to its direct role in breast cancer cells. Our study showed that the expression of SIX4 was profoundly increased in breast cancer tissues, and the high expression of SIX4 correlated strongly with distant metastasis and poor prognosis. Functional experiments demonstrated that SIX4 obviously promoted the cell migration and invasion of breast cancer cells, and up-regulated the expression of EMT mesenchymal marker, down-regulated the epithelial molecules by Snai1 induction in vitro. Moreover, SIX4 knockdown significant suppressed breast cancer lung metastasis in vivo. Mechanistically, SIX4 directly interacted with STAT3 and promoted the phosphorylated STAT3 nuclear translocation, thereby inducing EMT program activation. Collectively, our findings demonstrated that SIX4 may be a promising target for intervention to prevent cancer metastasis. AJCR Copyright © 2020.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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出版当年[2018]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.6 最新[2023版] 4.5 最新五年平均 4.737 出版当年[2018版] 4.44 出版当年五年平均 3.998 出版前一年[2017版] 5.177 出版后一年[2019版]

第一作者：

第一作者单位： [1]Department of GI Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China. [2]Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University Shihezi 832000, Xinjiang, P. R. China.

通讯作者：

通讯机构： [1]Department of GI Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China. [*1]Department of GI Cancer Research Institute,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, P. R. China.

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