单位：[a]No.3 People's Hospital of Chengdu, Chengdu 610031, China[b]Department of Cardiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China华中科技大学同济医学院附属同济医院内科学系心血管内科
Objective: The purpose of our study is to observe the voltage-gated potassium channel Kv1.3 expressed on CD4+CD28nullT cells from the peripheral blood of acute coronary syndrome (ACS) patients by the patch clamp technique. Methods: Kv1.3 potassium channels expression from 17 patients with ACS and 11 healthy age-match controls was detected in single cell(CD4 +CD28nullT cells and CD4+CD28+T cells) by fluorescence microscopy and patch clamp. Results: The percentage of CD4+CD28nullT cells was higher in the ACS patients [(6.97±2.05)%] than that in the controls [(1.38±0.84)%, P<0.05]. The concentration of hsCRP was directly correlated with the number of the CD4+CD28nullT cells in the ACS patients (r=0.52, P<0.05). The conductance (6.89±1.17ns vs 3.36±0.66ns), dens (1.95±0.80 μm2 vs 1.13±0.57 μm2) and numbers (574.5±97.6 n/cell vs. 280.3±55.3 n/cell) of the Kv1.3 channels on the CD4+CD28nullT cells were significantly higher than those on the CD4+CD28+T cells (all P<0.01) in ACS patients, but were similar on CD4+D28+T between ACS patients and controls. Conclusion: The CD4+CD28nullT cells and the numbers of Kv1.3 channels on the CD4+CD28 nullT cells from patients with ACS are significantly upregulated and might contribute to the pathogenesis of ACS.
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外文
中科院(CAS)分区：
出版当年[2009]版：
无
最新[2025]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区老年医学
第一作者：
第一作者单位：[a]No.3 People's Hospital of Chengdu, Chengdu 610031, China
通讯作者：
推荐引用方式(GB/T 7714)：
Huang S,Zhang C.-T,Tang J.-R,et al.Upregulated voltage-gated potassium channel Kv1.3 on CD4 +CD28null T lymphocytes from patients with acute coronary syndrome[J].Journal of Geriatric Cardiology.2010,7(1):
APA：
Huang, S,Zhang, C.-T,Tang, J.-R,Tang, J,Cai, L...&Zhou, M.-G.(2010).Upregulated voltage-gated potassium channel Kv1.3 on CD4 +CD28null T lymphocytes from patients with acute coronary syndrome.Journal of Geriatric Cardiology,7,(1)
MLA：
Huang, S,et al."Upregulated voltage-gated potassium channel Kv1.3 on CD4 +CD28null T lymphocytes from patients with acute coronary syndrome".Journal of Geriatric Cardiology 7..1(2010)
