Objective: The effects of hydrocortisone sodium succinate on voltage-gated sodium current (I(Na)) were investigated by using the patch-clamp technique in trigeminal ganglion (TG) neurons of rat. Methods: INa was recorded by whole-cell patch-clamp techniques after different concentrations of hydrocortisone sodium succinate were perfused in TG neurons of rat. Results: The results showed that hydrocortisone sodium succinate could inhibit INa in concentrationdependent manner. Hydrocortisone sodium succinate 0.1, 0.3, 1, 3 mu mol/l reduced INa by 19.4 +/- 4.3, 26.7 +/- 3.9, 38.1 +/- 6.1, 69.6 +/- 5.4% respectively. The IC(50) was 1.58 mu mol/l. This inhibitory effect occurred quickly (within 1 minute). However, hydrocortisone sodium succinate had no significant effect on the activation and inactivation courses of I(Na). Conclusion: It is suggested that the rapid inhibition of I(Na) in TG neurons by hydrocortisone sodium succinate is probably related to non-genomic effect. This inhibition might participate in the relaxation of pain in some emergency states.
基金：
Natural Science Foundation of Hubei Province of China [3080031]; National Science Foundation of China [309711800]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li He,Hui Fu,Jianmin Xiao.Effects of hydrocortisone sodium succinate on voltage-gated sodium current in trigeminal ganglion neurons of rat[J].NEUROLOGICAL RESEARCH.2011,33(3):295-299.doi:10.1179/016164110X12714125204515.
APA：
Li, He,Hui, Fu&Jianmin, Xiao.(2011).Effects of hydrocortisone sodium succinate on voltage-gated sodium current in trigeminal ganglion neurons of rat.NEUROLOGICAL RESEARCH,33,(3)
MLA：
Li, He,et al."Effects of hydrocortisone sodium succinate on voltage-gated sodium current in trigeminal ganglion neurons of rat".NEUROLOGICAL RESEARCH 33..3(2011):295-299
