单位：[a]Department of Gastroenterology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China华中科技大学同济医学院附属同济医院消化内科[b]Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China华中科技大学同济医学院附属同济医院器官移植研究所器官移植
AIM: To investigate the value of combined detection of serum alpha-fetoprotein (AFP), tumor-associated substances (TSGF) and carcinoembryonic antigen (CEA) in the diagnosis of primary hepatic carcinoma (PHC). METHODS: Serum samples from 100 patients with primary hepatic carcinoma (PHC group), 100 patients with benign liver disease (benign liver disease group) and 100 healthy individuals (control group) were used to detect the contents of AFP, TSGF and CEA by electrochemical luminescence immunoassay and biochemical colorimetric assay. RESULTS: In the PHC group, the positive rate of combined detection of AFP, TSGF and CEA was 95%, significantly higher than those of detection of AFP (70%), TSGF (61%) or CEA (57%) alone (all P < 0.05). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the combined detection method were significantly higher than those of detection of a single tumor marker (all P < 0.05). After treatment, serum levels of AFP, TSGF and CEA significantly declined in PHC patients when compared with pre-treatment values (all P < 0.01). CONCLUSION: Combined detection of AFP, TSGF and CEA can not only improve the diagnosis of PHC, especially in AFP-negative patients, but also help make a differential diagnosis between benign and malignant liver tumors.
语种：
中文
第一作者：
第一作者单位：[a]Department of Gastroenterology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Q,Zhang Q,Wei L.Differential diagnosis of primary hepatic carcinoma by detecting serum alpha-fetoprotein, tumor-associated substances and carcinoembryonic antigen[J].世界华人消化杂志.2010,18(18):
