单位：[1]Department of Respiratory and Critical Care Medicine, Tongji Hospital, Schoolof Medicine, Tongji University, Shanghai 200065, China[2]Key Laboratoryof Spine and Spinal Cord Injury Repair and Regeneration (Tongji University),Ministry of Education, Shanghai 200065, China[3]Shanghai General Hospital,100 Haining Road, Shanghai 200080, China[4]Department of Respiratoryand Critical Care Medicine, Ren Ji Hospital, School ofMedicine, Shanghai JiaoTong University, 160 Pujian Road, Shanghai 200127, China[5]Departmentof Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, TongjiUniversity School of Medicine, Shanghai 200433, China[6]Department of Respiratoryand Critical Care Medicine, Shanghai General Hospital, 100 HainingRoad, Shanghai 200080, China[7]Tongji University Cancer Center, ShanghaiTenth People’s Hospital, Tongji University School of Medicine, 301 YanchangRoad, Shanghai 200072, China[8]Wuhan Jinyintan Hospital, Wuhan 430023,China
The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known.The aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism.The retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively.In total, 304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.020). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell-cell communication.This study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell-cell communication of developing neutrophils and type II pneumocyte.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区医学
小类|3 区危重病医学
最新[2025]版：
大类|1 区医学
小类|2 区危重病医学
第一作者：
第一作者单位：[1]Department of Respiratory and Critical Care Medicine, Tongji Hospital, Schoolof Medicine, Tongji University, Shanghai 200065, China[2]Key Laboratoryof Spine and Spinal Cord Injury Repair and Regeneration (Tongji University),Ministry of Education, Shanghai 200065, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Runzhi Huang,Tong Meng,Qiongfang Zha,et al.The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019.[J].Critical care (London, England).2021,25(1):234.doi:10.1186/s13054-021-03661-y.
APA：
Runzhi Huang,Tong Meng,Qiongfang Zha,Kebin Cheng,Xin Zhou...&Ruilin Liu.(2021).The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019..Critical care (London, England),25,(1)
MLA：
Runzhi Huang,et al."The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019.".Critical care (London, England) 25..1(2021):234
医学